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Nanaomycin A
CAS No. 52934-83-5
Nanaomycin A ( —— )
Catalog No. M26770 CAS No. 52934-83-5
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1735 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNanaomycin A
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NoteResearch use only, not for human use.
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Brief DescriptionNanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
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DescriptionNanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM). (In Vitro):Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorApoptosis; Nucleoside Antimetabolite/Analog
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Research Area——
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Indication——
Chemical Information
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CAS Number52934-83-5
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Formula Weight302.3
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Molecular FormulaC16H14O6
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H]1O[C@@H](CC(O)=O)CC2=C1C(=O)c1c(O)cccc1C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25(20):4093-7.
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